| 機能 | Windows OS |
| サーバ(SafeBoot Communications ManagerおよびSafeBoot Server) | 対象OS | Windows 2000 Advanced Server | SP4 |
| Windows 2000 Server | SP4 |
| Windows Server 2003 Enterprise Edition (32bit) | SP1, SP2 |
| Windows Server 2003 Standard Edition (32bit) | SP1, SP2 |
| Windows Server 2003 Enterprise Edition R2 (32bit) | SP1, SP2 |
| Windows Server 2003 Standard Edition R2 (32bit) | SP1, SP2 |
| Windows Server 2003 Enterprise Edition (64bit) | SP1, SP2 |
| Windows Server 2003 Standard Edition (64bit) | SP1, SP2 |
| Windows Server 2003 Enterprise Edition R2 (64bit) | SP1, SP2 |
| Windows Server 2003 Standard Edition R2 64bit) | SP1, SP2 |
| 対象OS言語※1 | 日本語 |
| 管理システム(SafeBoot Administration) | 対象OS | Windows 2000 Advanced Server | SP4 |
| Windows 2000 Server | SP4 |
| Windows Server 2003 Enterprise Edition (32bit) | SP1, SP2 |
| Windows Server 2003 Standard Edition (32bit) | SP1, SP2 |
| Windows Server 2003 Enterprise Edition R2 (32bit) | SP1, SP2 |
| Windows Server 2003 Standard Edition R2 (32bit) | SP1, SP2 |
| Windows Server 2003 Enterprise Edition (64bit) | SP1, SP2 |
| Windows Server 2003 Standard Edition (64bit) | SP1, SP2 |
| Windows Server 2003 Enterprise Edition R2 (64bit) | SP1, SP2 |
| Windows Server 2003 Standard Edition R2 64bit) | SP1, SP2 |
| Windows XP Home Edition | SP2, SP3※3 |
| Windows XP Professional Edition | SP2, SP3※3 |
| Windows Vista Business Edition(32bit) | SPなし, SP1 |
| Windows Vista Enterprise Edition(32bit) | SPなし, SP1 |
| Windows Vista Ultimate Edition(32bit) | SPなし, SP1 |
| Windows Vista Home Basic Edition(32bit) | SPなし, SP1 |
| Windows Vista Home Premium Edition(32bit) | SPなし, SP1 |
| 対象OS言語※1 | 日本語 |
| McAfee Endpoint Encryption for Devicesクライアント | | Windows 2000 Professional | SP4 |
| Windows XP Home Edition | SP2, SP3※3 |
| Windows XP Professional Edition | SP2, SP3※3 |
| Windows Vista Business Edition(32bit) | SPなし, SP1 |
| Windows Vista Business Edition(64bit) | SPなし, SP1 |
| Windows Vista Enterprise Edition(32bit) | SPなし, SP1 |
| Windows Vista Enterprise Edition(64bit) | SPなし, SP1 |
| Windows Vista Ultimate Edition(32bit) | SPなし, SP1 |
| Windows Vista Ultimate Edition(64bit) | SPなし, SP1 |
| Windows Vista Home Basic Edition(32bit) | SPなし, SP1 |
| Windows Vista Home Basic Edition(64bit) | SPなし, SP1 |
| Windows Vista Home Premium Edition(32bit) | SPなし, SP1 |
| Windows Vista Home Premium Edition(64bit) | SPなし, SP1 |
| 対象OS言語※1 | 日本語 |
| 英語※2 |
| McAfee Endpoint Encryption for Files and Foldersクライアント※4 | | Windows 2000 Professional | SP4+RollUp1 |
| Windows XP Home Edition | SP2, SP3※3 |
| Windows XP Professional Edition | SP2, SP3※3 |
| Windows Vista Business Edition(32bit) | SPなし, SP1 |
| Windows Vista Enterprise Edition(32bit) | SPなし, SP1 |
| Windows Vista Ultimate Edition(32bit) | SPなし, SP1 |
| Windows Vista Home Basic Edition(32bit) | SPなし, SP1 |
| Windows Vista Home Premium Edition(32bit) | SPなし, SP1 |
| 対象OS言語※1 | 日本語 |
| 英語※2 |
※3 Windows XP SP2, SP3はセキュリティ強化に伴う問題が発生しますが、Windowsのファイアウォール設定を正しく行うことにより正常に動作します。